1) Which ocular DDS has the largest particle size among these?
a. Liposome
b. Niosomes
c. Discosome
d. Liposome and Niosome
2) Water content in Eye is a.95%
b.98% c.96% d.97%
3) Which factor not affects ocular absorption?
a. GI pH
b. Lacrimal drainage
c. Dilution of dose
d. Protein in lacrimal fluid
4. Which ocular DDS from following have maximum contact time
a. Ointment
b. Oily eye drop
c. Ocular road
d. Eye lotion
5. Which property is not ideal for ocular DDS
a. Sterility
b. Isotonicity
c. Less drainage tendency
d. Maximum protein binding
6. Matting of eyelid is side effect of
a. Eye ointment
b. Eye gel
c. Both eye ointment and eye gel
d. Ocusert
7. Which is not a erodible type of ocular DDS among these
a. Lacrisert
b. Ocusert
c. SODI
d. Minidisc
8. Which is not the property of TDDS
a. Non invasive
b. Sustained effect
c. GI irritation
d. Self-administration
9. Which factor not affects transdermal absorption?
a. Thickness of liner layers b.Skin pH.
c. Surface area of patch
d. Thickness of skin
10. For transdermal absorption, the drug must pass through
a. Baking layer
b. Liner layer
c. Adhesive layer
d. Blood
11. Which test is not used to determine the tackiness of transdermal patch?
a. Thumb test
b. Probe test
c. Peel adhesion test
d. Rolling ball test
12. Which is not a limitation of TDDS?
a. High molecular weight
b. High dose of drug
c. Low molecular weight
d. All of these
13. Which GRDDS technique required external assistance?
a. Floating approach
b. Muco-adhesive approach
c. Magnetic approach
d. Sinking approach
14. Zinc oxide and titanium oxide used in which GRDDS approach?
a. Low density systems
b. High density systems
c. Magnetic systems
d. Swelling systems
15. In which portion of the stomach, food stored?
a. Pyloric
b. Body
c. Cardia
d. Lesser curvature
16. For high-density system, the density should be in the range
a. 1-2 gm/ml
b. 1.5-2.1 gm/ml
c. 1.7-2.3 gm/ml
d. 09-1.7 gm/ml
17. Which is an ideal condition for GRDDS
a. Low fluid in stomach
b. Retention of GRDDS in antrum part
c. Achlorhydria
d. Drug having narrow therapeutic index
18. Which is not the advantage of colon specific drug delivery system (CSDDS)?
a. Higher absorption of protein and peptide drugs
b. Lower drug degradation
c. Site specific delivery
d. Higher absorption of drug from small intestine
19. Inflammatory bowel disease related to
a. Stomach
b. Colon
c. Rectum
d. Pylorus
20. Which dosage form is not related to colon specific drug delivery system (CSDDS)?
a. DOTS
b. OROS-CT
c. PULSINCAP
d. CODES
21. Which is not the disadvantage of colon specific drug delivery system (CSDDS)?
a. Drug degradation of microbial flora
b. Small luminal surface area
c. Slow onset of action
d. Prolonged drug release
22. .Keratinized oral epithelial layer
a. Increase bioavailability
b. Decrease bioavailability
c. No effect on bioavailability
d. Enhance solubility
23. which is the right sequence of the mechanism of bio adhesion in mucosal DDS?
a. swelling>wetting>inter penetration> entanglement>chemical bond
b. wetting>swelling>inter penetration> entanglement>chemical bond
c. wetting>swelling>chemical bond>entanglement> inter penetration
d. wetting>swelling>entanglement>inter penetration>chemical bond
24. .Which API is suitable for mucosal DDS?
a. With high biological half life
b. Mol. Wt. more than 1000 D
c. Irritant to buccal mucosa
d. Drug degraded in GI tract
25. “Arion lustanicus” is used in which the evaluation test of mucosal DDS
a. Hygroscopicity test
b. Folding endurance test
c. Slug irritation assay
d. In-vitro residence time
26. Which is not the part of the upper respiratory tract?
a. Nasal cavity
b. Trachea
c. Larynx
d. Pharynx
27. What is the thickness of alveolar sac? a. 0.1-0.2 μm
b. 1-2 μm
c. 11-12 μm
d. 4-8 μm
28. Which is not the mechanism of drug deposition in the airways?
a. Gravitational sedimentation
b. Impactation
c. Brownian diffusion
d. Entanglement
28.0.5 μm or less sized particles deposit by which mechanism in lungs
a. Gravitational sedimentation b.Impactation
c. Brownian diffusion d.Interception
29. Why spacers used with inhalers?
a. Better patient compliance
b. Drug deposition in lungs
c. Site specific action
d. All of these
30. he absorption of the ophthalmic drug does not depend on which of the following?
a. Physicochemical properties of the permeating molecule
b. Drainage of tears
c. Output of tears
d. Size of the eyeball
31. Which of the following should not be a property of implants?
a. Environmental stable
b. Biostable
c. Non-toxic
d. Nonremovable
32. Which of the following is a characteristic of nanoparticles?
a. Free flowing powders
b. Size range 10-100 nm
c. Control drug release by partitioning the drug from the oil
d. Aqueous solutions
33. Which of the following is a characteristic of resealed erythrocytes?
a. Nonimmunogenic
b. Aqueous solutions
c. Control drug release by partitioning the drug from the oil
d. Size range 10-100 nm
34. Which of the following statement is false for osmotic pumps?
a. The pump has three concentric circle
b. The innermost is the drug reservoir
c. The drug is contained a permeable polyester bag
d. Outer most rigid rate controlling semipermeable membrane
35. What is the characteristic of altered density systems?
a. The dosage form either sink or float in stomach
b. The dosage form dissolve rapidly
c. The dosage form is liquid in nature
d. Drug release is observed in small intestine only
36. What is the characteristic of mucoadhesive systems in GRDDS?
a. The dosage form is liquid in nature b Free flowing powders
c. Usage of bio adhesive polymer
d .Use of high or low density pellets
37. Enteric coating is used for which systems?
a. Mucoadhesive systems
b. Size based systems
c. Intestinal release systems
d. Buccal drug delivery systems
38. What is the characteristic of colonic release systems?
a. Release the drug along the entire length of GIT
b. Prolonged their residence in the GIT and release
c. Usage of polymers that dissolves only in the alkaline pH of colon
d. Use of enteric coating
39. The disadvantage for implants is-
a. More effective
b .More prolonged action
c. Significantly small dose
d. Need of microsurgery
40. Name two different types of inhaler?
a. MDI and API
b. IV and SC
c. DPI and MDI
d. GIT and AT
41. What are the characteristics of the reservoir or membrane devices?
a. The drug has a large therapeutic index
b. Drug permeation rate is high
c. Control drug release by partitioning the drug from the oil
d. Administration of emulsions
42. Factors to be considered in designing of colon specific drug delivery is
a. Diameter of lumen of colon
b. Refractive index of drug
c. Available dosage form
d. Colonic microflora
43. Name the approach of colon specific drug delivery in which hydrolysis of sulfasalazine in to 5-amino salicylic acid and sulphapyridine is carried out
a. Coating with azo polymers
b. Prodrug
c. Hydrogels
d. Polysacharides as carriers
44. Full form of SODI is
a. Soluble ocular direct injection
b. Soluble ocular drug insert
c. Soluble diffusion implants
d. Soluble dissolution implants
45. Which statement is not correct about transdermal route of administration?
a. It avoids first pass metabolism
b. It avoids gastric irritation
c. Bitter taste drug can be given by Transdermal dosage forms
d. Freely water soluble drug can be easily given by transdermal route of administration
46. Which statement is correct about Gastroretentive drug delivery system?
a. Drug should show absorption in stomach only
b. Dose of the drug should be as low as possible
c. Drug should be water soluble
d. Drug should be water insoluble
47. Polymer membrane permeation- controlled drug delivery occurs by
a. Non porous membrane
b. Micro porous membrane
c. Semi permeable membrane
d. All of the above
48. Alzet Pump is an example of
a. Osmotic pressure activated
b. Vapor pressure activated
c. Magnetically activated
d. Hydrolytic-activated
49. Which of the following is incorrect for conventional drug delivery for ocular drug delivery?
a. Less Bioavailability
b. Protein binding
c. Lacrimation
d. Long residence time
50. Which animal is used in pharmacokinetic evaluation of Buccal drug delivery system
a. Rat
b. Mouse
c. Guinea pigs
d. Rabbit
51. Colon targeted drug delivery system is used for
a. Local action
b. Systemic action
c. Topical action
d. All of the above
52. In dendrimer synthesis assembly of molecule from core, extending radially to the periphery is known as
a. Convergent synthesis
b. Divergent synthesis
c. Double exponential
d. Chemical Synthesis
53. In dendrimer synthesis when a critical branched state is reached which cannot further grow due to lack of space is known as
a. Star Bust effect
b. Star Rust effect
c. Star Galaxy effect
d. None of the above
54. Ophthalmic dosage forms should be
a. Liquid
b. Solid
c. Sterile
d. Partially sterile
55. Under normal conditions the human tear volume averages about
a. 7 microliters
b. 10 microliters
c. 25 microliters
d. 15 microliters
56. Heat-sensitive ophthalmic formulation may be sterilized by
a. Moist heat sterilization
b. Dry heat sterilization
c. Boiling with chemicals
d. Gaseous sterilization
57. The weight of sodium chloride that will produce the same osmotic effect as 1 g of the drug is known as
a. E value
b. B Value
c. D value
d. A value
59. Increased intraocular pressure is one of the symptoms of
a. Conjunctivitis
b. Glaucoma
c. Diabetic Retinopathy
d. None of the above
60 .The time for which the dosage form continuously floats on the dissolution media is termed as
a. Floating Time
b. Buoyancy lag time
c. Floating lag time
d. None of the above
ANSWER
Question Answer Question Answer Question Answer Question Answer Question Answer Question Answer
1 C 11 C 21 D 31 D 41 C 51 D
2 B 12 C 22 B 32 D 42 C 52 D
3 A 13 C 23 B 33 B 43 D 53 B
4 C 14 B 24 D 34 A 44 B 54 A
5 D 15 C 25 C 35 C 45 B 55 C
6 C 16 B 26 B 36 A 46 D 56 A
7 B 17 B 27 A 37 C 47 A 57 C
8 C 18 C 28 D 38 C 48 D 58 A
9 A 19 B 29 C 39 C 49 A 59 B
10 C 20 A 30 D 40 D 50 A 60 B