1.13C Octanoic acid Breath test is used in evaluation of
A. GRDDS
B. Pulmonary DDS
C. Transdermal DDS
D. Nasal DDS
2. Which of the following characteristics is suitable for transdermal drug?
A. Large drug dose
B. Large molecular size
C. Drugs with narrow therapeutic indices
D. Drugs which are metabolized in the skin
3. What are the characteristics of the monolithic devices?
A. The drug has a large therapeutic index
B. Aqueous solutions
C. Control drug release by partitioning the drug from the oil
D. Administration of emulsions
4. The absorption of the ophthalmic drug does not depend on which of the following?
A. Physicochemical properties of the permeating molecule
B. Drainage of tears
C. Output of tears
D. Size of the eyeball
5. The anterior transparent part of the eye is
A. Pupil
B. Conjunctiva
C. Cornea
D. Sclera
6. The nerve which is responsible for the vision is
A. Olfactory
B. Facial
C. Optic
D. Acoustic
7. Light rays entering the eyes is controlled by
A. Pupil
B. Iris
C. Cornea
D. Lens
8. Fluid in the posterior chamber of the eyes is called as
A. Vitreous fluid
B. Aqueous fluid
C. Both
D. None
9. Which is the innermost layer of eyes
A. Sclera
B. Retina
C. Cornea
D. Iris
10. In the following which organ is not related to respiratory system
A. Larynx
B. Pharynx
C. Oesophagus
D. Bronchi
11. Nasal administration is commonly used for the relief of?
A. Headache
B. Cough
C. Sore throat
D. Congestion
12. Which of the following formulations would not be applicable to ocular administration?
A. Solution
B. Liniment
C. Suspension
D. Ointment
13. Which one of the following medicines does not rely on topical drug delivery?
A. Nasal spray
B. Anti-dandruff shampoo
C. Insulin pen
D. Nicotine patch
14. Which component enhance percutaneous absorption
A. Lactose
B. DMSO
C. Fructose
D. HPMC
15. Colon targeted drug delivery system is used for
A. Local action
B. Systemic action
C. Topical action
D. All of the above
16. The pH in the stomach usually is between A. 1-3
B. 3-5
C. 5-7
D.7-9
17 The gastric emptying time at small intestine commonly is
A. 1-2 hrs
B. 3-4 hrs
C. 7-8 hrs
D. 12-24 hrs
18. The enzymes that are mainly targeted for colon drug delivery include
A. Azoreducatase-galactosidase
B. Î’-xylosidase
C. Nitroreductase
D. All of the above
19. Mucosa is covered by
A. Islet cells
B. Beta cells
C. Goblet cells
D. Alpha cells
20. Which of the following is not one of the theories of muco-adhesion
A. Electronic theory
B. Wetting theory
C. Adsorption theory
D. Adhesion theory
21. Mucoadhesive drug delivery system are not available for
A. Ocular
B. Nasal
C. Buccal
D. Topical
22. Which of the following are used as penetration enhancers?
A. Benzalkonium chloride
B. Dextran sulfate
C. Fatty acid
D. All of the above
23. Which of the following is not a nasal region?
A. Nasal vestibule
B. Olfactory region
C. Respiratory region
D. Circulatory region
24. Which of the following is not a component of mucus?
A. Protein
B. Lipid
C. Sugar
D. Salt
25. In pulmonary drug absorption the lipophilic drug follow
A. Paracellular transport
B. Transcellular transport
C. Endocellular
D. Both A and B
26. In DPI the particle size should be less than
A. 5 μm
B. 0.5 μm
C. 50 μm
D. 500 μm
27. In liposome which ingredient causes big changes in the membrane?
A. Surfactant
B. Phospholipid
C. Cholesterol
D. None of the these
28 For liposome preparation, which of the following is not a mechanical dispersion method?
A. Lipid film hydration
B. Sonication
C. French pressure cell
D. Ethanol injection
29. Factor which affect gastro retentive system
A. Size
B. Shape
C. Density
D. All of the above
30. In transdermal drug penetration the rate limiting layer is
A. Stratum corneum
B. Stratum granulosum
C. Stratum spinosum
D. Stratum germinativum
31. The diameter of small unilamellar vesicles is
A.20nm-100nm B.20nm-1000nm C.10nm-100nm D.20nm-400nm
32. Liposomes phospholipid undergoes
A. Oxidation
B. Hydrolysis
C. Acetylation
D. Both a and b
33. Liposomes have half life
A. Longer
B. Shorter
C. Intermediate
D. Both a and b
34. Liposomes have solubility
A. Lower
B. Higher
C. Both a and b
D. None of the these
35. Liposomes consist of a bilayer of
A. Hydrophilic molecules
B. Hydrophobic molecules
C. Both a and b
D. None of the these
36. Liposomes are spherical structures , usually between in diameter
A. 80nm-100nm
B. 60nm-100nm
C. 55nm-1000nm
D. 15nm-1000nm
37. Intermediate sized unilameller vesicles are prepared by
A. Sonication
B. High pressure extrusion technique
C. Detergent dialysis
D. Both b and c
38. Tranfersome belongs to the classification according to
A. Compostion
B. Application
C. Function
D. None of the these.
39. Liposomes with number of lamella are called as “ pauci-lamellar liposomes”
A. Lower
B. Higher
C. Single
D. None of the these
40. Amphotericin B liposomes are given
A. Lungs
B. Oral
C. Transdermal
D. Interavenous
41. Ketoconazole liposomes are given
A. Lunges
B. Oral
C. Transdermal
D. Interavenous
42. Temperature used for ether injection method is or under reduced pressure A.15-250C
B.55-650C C.55-850C
D. None of the these
43. Nasal administration is commonly used for the relief of?
A. Headache
B. Cough
C. Sore throat
D. Congestion
44. Which of the following formulations would not be applicable to ocular administration?
A. Solution
B. Liniment
C. Suspension
D. Ointment
45. Which one of the following medicines does not rely on topical drug delivery?
A. Nasal spray
B. Anti-dandruff shampoo
C. Insulin pen
D. Nicotine patch
46. Which component enhance percutaneous absorption
A. Lactose
B. DMSO
C. Fructose
D. HPMC
47. Colon targeted drug delivery system is used for
A. Local action
B. Systemic action
C. Topical action
D. All of the above
48. The pH in the stomach usually is between A. 1-3
B. 3-5
C. 5-7
D.7-9
49. The gastric emptying time at small intestine commonly is
A. 1-2 hrs
B. 3-4 hrs
C. 7-8 hrs
D. 12-24 hrs
50. The enzymes that are mainly targeted for colon drug delivery include
A. Azoreducatase-galactosidase
B. Î’-xylosidase
C. Nitroreductase
D. All of the above
51. Mucosa is covered by
A. Islet cells
B. Beta cells
C. Goblet cells
D. Alpha cells
52. Which of the following is not one of the theories of muco-adhesion
A. Electronic theory
B. Wetting theory
C. Adsorption theory
D. Adhesion theory
53. Mucoadhesive drug delivery system are not available for
A. Ocular
B. Nasal
C. Buccal
D. Topical
54. Which of the following are used as penetration enhancers?
A. Benzalkonium chloride
B. Dextran sulfate
C. Fatty acid
D. All of the above
55. Which of the following is not a nasal region?
A. Nasal vestibule
B. Olfactory region
C. Respiratory region
D. Circulatory region
56. Which of the following is not a component of mucus?
A. Protein
B. Lipid
C. Sugar
D. Salt
57. In pulmonary drug absorption the lipophilic drug follow
A. Paracellular transport
B. Transcellular transport
C. Endocellular
D. Both A and B
58. In DPI the particle size should be less than
A. 5 μm
B. 0.5 μm
C. 50 μm
D. 500 μm
59. In liposome which ingredient causes big changes in the membrane?
A. Surfactant
B. Phospholipid
C. Cholesterol
D. None of the these
60. For liposome preparation, which of the following is not a mechanical dispersion method?
A. Lipid film hydration
B. Sonication
C. French pressure cell
D. Ethanol injection
Answer
Question Answer Question Answer Question Answer Question Answer Question Answer Question Answer
1 A 11 D 21 A 31 A 41 B 51 C
2 C 12 B 22 A 32 D 42 B 52 D
3 A 13 B 23 D 33 B 43 D 53 A
4 D 14 B 24 C 34 A 44 B 54 A
5 C 15 A 25 B 35 C 45 B 55 D
6 C 16 A 26 A 36 D 46 B 56 C
7 B 17 A 27 B 37 D 47 A 57 B
8 B 18 A 28 D 38 A 48 A 58 A
9 B 19 C 29 D 39 B 49 A 59 B
10 C 20 d 30 a 40 C 50 A 60 D
PH-IX SET II
1 Pharmaceutical Analysis- IV
1. Column chromatography is based on the principle of
● a) Ion-exchange
● b) Exclusion principle
● c) Differential adsorption
● d) Absorption
2. Arrange the following compounds in order of their increasing adsorption tendencies.
● a) Cellulose >> starch >> calcium carbonate >> alumina
● b) Cellulose >> starch >> alumina >> charcoal
● c) Charcoal >> cellulose >> alumina >> starch
● d) Calcium carbonate >>; alumina >> starch >> cellulose
3 What is the factor responsible for the separation in column chromatography?
● a) Polarity differences between the solvent
● b) Polarity differences between the solute
● c) Polarity indifference between the solvent
● d) Polarity indifference between the solute
4 Select the correct statement from the following options.
● a) The lesser the polarity of solute, more strongly it will be adsorbed on a polar surface
● b) The greater the polarity of solute, more weakly it will be adsorbed on a polar surface
● c) The greater the polarity of solute, more strongly it will be adsorbed on a polar surface
● d) All of the mentioned option
5 The correct order of increasing strength of adsorption is
● a) Alkanes >> Esters >> Aldehydes >> Phenols >> Ketones
● b) Aldehydes >> Phenols >> Ketones >> Esters >> Alkanes
● c) Aldehydes >> Ketones >> Esters >> Alkanes >> Phenols
● d) Alkanes >> Esters >> Ketones >> Aldehydes >> Phenols
6 The components of the mixture in column chromatography are eluted in order of
● a) Increasing polarity and decreasing distribution ratio
● b) Increasing polarity and increasing distribution ratio
● c) Decreasing polarity and increasing distribution ratio
● d) Decreasing polarity and decreasing distribution ratio
7 The elution power of a solvent is determined by
● a) Its overall polarity
● b) The polarity of the stationary phase
● c) The nature of the sample components
● d) All of the mentioned
8 Which of the following is separated through column chromatography?
● a) Chlorophyll and carotenoids
● b) Inorganic cations or complexes
● c) Sugar derivatives
1 Pharmaceutical Analysis- IV
● d) Amino acids formed by hydrolysis of a protein molecule
9 The mixture of petroleum ether and benzene is used in the elution ratio of
● a) 1 : 2
● b) 1 : 5
● c) 1 : 9
● d) 1 : 12
10 Chloroform fraction is eluted from the column by passing chloroform through the column which acts as
● a) Eluter
● b) Eluant
● c) Elution
● d) None of the mentioned option
11 For the separation of which of the following substances, Gas-solid chromatography is being used?
● a) Thermally stable organic components
● b) Volatile organic components
● c) Thermally stable inorganic components
● d) Low molecular weight gaseous species
12 Which of the following is not a feature of carrier gas used in gas chromatography?
● a) It must be chemically inert
● b) It should be suitable for the detector employed
● c) It should not be completely pure
● d) It should be cheap
13 Which of the following is the disadvantage of hydrogen, which can be used as carrier gas in gas chromatography?
● a) Dangerous to use
● b) Expensive
● c) Reduced sensitivity
● d) High density
14 Which of the following is the disadvantage of helium, which can be used as carrier gas in gas chromatography?
● a) Dangerous to use
● b) Expensive
● c) Reduced sensitivity
● d) High density
15 Which of the following is the disadvantage of nitrogen, which can be used as carrier gas in gas chromatography?
● a) Dangerous to use
● b) Expensive
● c) Reduced sensitivity
1 Pharmaceutical Analysis- IV
● d) High density
16 Slow injection of large samples leads to band broadening and loss of resolution.
● a) True
● b) False
17 In which of the following methods are liquid samples injected into the column in gas chromatography?
● a) Gas tight syringe
● b) Micro-syringe
● c) Rotary sample valve
● d) Solid injection syringes
18 What must be done to the solid samples for it to be introduced into the column without using solid injection syringes in gas chromatography?
● a) Introduced in hot-zone of the column
● b) Dissolved in volatile liquids
● c) Introduced using rotary sample valve
● d) Introduced using sampling loops
19 Which of the following is the commonly used support material for the packed column in gas chromatography?
● a) Glass
● b) Metal
● c) Diatomaceous earth
● d) Stainless steel
20 Which of the following is the advantage of a straight packed column?
● a) It can be packed uniformly
● b) It can be repacked easily
● c) It is compact
● d) It is easier to heat it evenly
21 Which of the following is the disadvantage of coiled or helical shaped packed chromatographic column?
● a) It cannot be packed uniformly
● b) It cannot be repacked easily
● c) It is not compact
● d) It is not easy to heat it evenly
22 Capillary columns are open tubular columns constructed from which of the following materials?
● a) Glass
● b) Metal
● c) Stainless steel
● d) Fused silica
1 Pharmaceutical Analysis- IV
23 Sample injection port must be maintained at a temperature at which rapid vapourisation occurs but thermal degradation does not occur.
● a) True
● b) False
24 Which of the following is not a desirable feature of the ovens used in gas chromatography?
● a) It must have a fast rate of heating
● b) Power consumption should be kept low
● c) It must have maximum thermal gradients
● d) It should have proper insulation
25 Which of the following is not true about High pressure liquid chromatography (HPLC)?
● a) It requires high pressure for the separation of the specious
● b) There is no need to vaporise the samples
● c) It is performed in columns
● d) It has high sensitivity
26 High pressure liquid chromatography can be performed only in columns.
● a) True
● b) False
27 Which of the following is not an advantage of Syringe type pumps used in High pressure liquid chromatography?
● a) Independent of viscosity
● b) Pulse-less flow
● c) High pressure capability
● d) Unlimited solvent capacity
28 Which of the following is not true about solvent programming which is done in high performance liquid chromatography?
● a) It provides unequal bandwidths
● b) It provides fast overall separation
● c) It provides maximum resolution
● d) It provides maximum sensitivity
29 Which of the following pulse damper takes up some amount of the pulsation energy which is released to provide smooth pressure without pulsations?
● a) Flexible bellows or compressible gas passed through tee columns
● b) Flexible inert diaphragm
● c) Electronic pulse damper
● d) Electrical pulse damper
30 Which of the following is not a characteristic of the syringe pump used in high pressure liquid chromatography?
● a) Pressure capability is high
● b) Maintenance is frequent
● c) Limited reservoir capability
1 Pharmaceutical Analysis- IV
● d) Slight change of flow rate when extremely high pressure compresses the solvent
31 Syringe pumps used in High pressure liquid chromatography are most suitable for which of the following columns?
● a) Capillary columns
● b) Guard columns
● c) Short-fast columns
● d) Small bore columns
32 Gravity feed method for solvent delivery is not used with narrow bore columns packed with fine mesh particles.
● a) True
● b) False
33 Which of the following cannot be done to reduce ripple in High pressure liquid chromatography?
● a) Using bellows
● b) Using restrictors
● c) Using long nylon tube between pump and column
● d) Avoiding the use of the solvent pump
34 Which of the following is not true about Hydraulic capacitance flow control system used in HPLC?
● a) It can be used only for liquids with low viscosity
● b) It is irrespective of solvent compressibility
● c) It maintains a constant flow
● d) It smoothens high pressure pump pulsations
35 Ion-exchange resin is
● a) Linear
● b) Low molecular weight
● c) Organic polymer with porous structure
● d) Soluble
36 Which of the following ion get released from the cation exchange column?
● a) H+
● b) Na+
● c) K+
● d) Ca+2
37 Which of the following ion get released from the anion exchange column?
● a) CO3-2
● b) OH–
● c) Cl–
● d) SO4-2
38 Ion-free water coming out from the exchanger is known as
● a) Potable water
1 Pharmaceutical Analysis- IV
● b) Disinfected water
● c) Coagulated water
● d) Demineralised water
39 Which of the following statement is incorrect about the demineralised water?
● a) It is as pure as distilled water
● b) It is very good for use in high pressure boilers
● c) It is fit for domestic use
● d) It can be made either by distillation or by using cation and anion exchangers
40 The exhausted cation exchange column is regenerated by passing a solution of
● a) Dil. HCl
● b) Dil. NaCl
● c) Conc. HCl
● d) Conc. NaCl
41 The exhausted anion exchange column is regenerated by passing a solution of
● a) Dil. KOH
● b) Conc. KOH
● c) Conc. NaOH
● d) Dil. NaOH
42 The raw water used for ion-exchange process should be turbid.
● a) True
● b) False
43 In ion-exchange process, the capital cost is and the operational expenses are
● a) Low, high
● b) High, low
● c) High, high
● d) Low, low
44 The residual hardness in ion-exchange process is
● a) 0-2 ppm
● b) 5-10 ppm
● c) 10-15 ppm
● d) 20-30 ppm
45 Vibrational spectroscopy involves the transitions falling in the spectral range of
● a)100-1000cm-1
● b)300-3000cm-1
● c)400-4000cm-1
● d) 500-5000 cm-1
46 Which of the region of IR spectra appears between (1400-600) cm-1?
● a) Functional group region
● b) Fingerprint region
● c) Low-frequency region
1 Pharmaceutical Analysis- IV
● d) None of the mentioned
47 Select the correct statement from the following option.
● a) Infrared spectra can identify the unknown materials
● b) It can determine the amount of components in a mixture
● c) It can also determine the quality of a sample
● d) All of the mentioned
48 Which of the following molecule have infrared active vibrations?
● a) NO
● b) CH4
● c) H2
● d) All of the mentioned
49 Which of the following cannot show a vibrational absorption spectrum?
● a) OCS
● b) H2O
● c) CO2
● d) C H2 = CH2
50 Which of the following is not a type of bending molecular vibration?
● a) Twisting
● b) Stretching
● c) Wagging
● d) Rocking
51 What is the absorption frequency(cm-1) of –C=N functional group?
● a) 3610-3640
● b) 1690-1760
● c) 1180-1360
● d) 2850-2960
52 Presence of a functional group in a compound can be established by using
● a) Chromatography
● b) IR spectroscopy
● c) Mass spectroscopy
● d) X-ray diffraction
53 Select the incorrect option from the following option.
● a) IR spectroscopy helps in the determination of purity
● b) IR spectroscopy helps in the determination of force constant from vibrational spectrum
● c) IR spectroscopy helps in identifying an unknown compound
● d) None of the mentioned
54 IR spectroscopy helps in detecting the presence of hydrogen bonding.
● a) True
● b) False
55 NMR spectroscopy is used for determining structure in which of the following materials?
● a) Radioactive Materials
1 Pharmaceutical Analysis- IV
● b) Insoluble Chemical compounds
● c) Liquids
● d) Gases
56 NMR is the study of absorption of by nuclei in a magnetic field?
● a) Radioactive radiation
● b) IR radiation
● c) Radio frequency radiation
● d) Microwaves
57 NMR spectrometer provides and method of determining structure in soluble chemical compounds.
● a) Accurate, destructive
● b) Accurate, non-destructive
● c) Inaccurate, destructive
● d) Inaccurate, non-destructive
58 NMR spectroscopy indicates the chemical nature of the & spatial positions of
● a) Electrons, Protons
● b) Neutrons, electrons
● c) Nuclei, electrons
● d) Nuclei, neighbouring nuclei
59 In NMR spectroscopy, the spinning nuclei in a strong magnetic field must be irradiated by ;which of the following?
● a) Perpendicular and stronger field
● b) Perpendicular and weaker field
● c) Parallel and stronger field
● d) Parallel and weaker field
60 Why TMS reference standard used in NMR Spectroscopy.
• a) Unreactive & it does not associate with the sample
• b) Symmetrical & it gives a sharp peak of 12 equivalent protons
• c) extremely volatile and allows recovery of the pure sample
• d) Soluble in most organic solvents. Methyl protons of TMS are strongly shielded
• e) a, b, c and d correct
Answers:
1 c 11 b 21 b 31 d 41 d 51 c
2 a 12 c 22 d 32 a 42 a 52 b
3 b 13 a 23 a 33 d 43 c 53 d
4 c 14 b 24 c 34 a 44 a 54 a
5 d 15 c 25 b 35 c 45 c 55 c
6 b 16 a 26 a 26 b 46 b 56 c
7 d 17 b 27 d 37 b 47 d 57 b
8 a 18 b 28 a 38 d 48 a 58 d
9 c 19 c 29 a 39 c 49 d 59 b
10 c 20 c 30 b 40 a 50 b 60 e