Unit 5 MEDICINAL CHEMISTRY – III Typing Notes B.Pharmacy

  

                                                   UNIT – V

Various approaches used in drug design :-

Defination :-  It is inventive process of finding new medicines based on the knowledge of a biological target.

    There are two types of drug design:-

          1. Ligand-based drug design

          2. Structure-based drug design

Advantages :-

1)    Time reduces

2)    Cost reduces

3)    Accuracy

4)    less manpower is required

5)    information about the disease

6)    screening is reduced

7)    Database screening

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Physicochemical parameters used in quantitative structure activity

relationship (QSAR) :-

1)    Hydrophobicity: partition coefficient, π -substitution constant

2)    Steric Parameters: Taft’s constant, verloop, steric parameter

3)    Electronic Parameter: Hammet constant, dipole moment

 

 

 

Pharmacophore modeling and docking technique :-

Defination :- Pharmacophore is a group of atoms in the molecule of a drug responsible for the drug's action.

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