B.PHARMACY
SEMESTER 7
NOVEL DRUG DELIVERY STSTEM(NDDS)
UNIT I
General mechanism of drug release thorough polymer:
Syllabus :
Controlled drug delivery systems: Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates.Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and biological properties of drugs relevant to controlled release formulations..
General mechanism of drug release thorough polymer:
Drug absorption and release are dynamic processes that have a strong effect on the effectiveness of prescription medicines. The release rate of a drug from its carrier depends on many factors such as the composition, structure and age of the patient. Polymers are substances formed from many repeating units of a same chemical substance. They are commonly used in medicine to modify drug rates of release. The use of polymers to modify drug rate of release is not a new concept; however, their use in medicine is still limited compared to their use in other fields such as engineering and manufacturing.
Different drugs have different release rates, which are determined by their structure and/or composition. For example, hydrocodone has a rapid release rate with compromising properties compared to buprenorphine, which has a slower but safer release rate with no psychoactive effects. Some drugs have similar properties that could be released at similar rates, such as beta blockers and selective serotonin reuptake inhibitors (SSRIs). The rapid release rate of SSRIs from polyethylene glycol (PEG) leads to severe drug malabsorption in the gut within 12-48 hours. Some drugs are poorly absorbed from the gut due to poor polymer selection. Polyethylene glycol (PEG) is one of the most common types of polymer used in medicine and has less effect on drug absorption than other types of polymers:
HANDWRITTEN NOTES: