Long-Term Use: What Happens When You Take Antihistamines Regularly?
Long-term use of antihistamines and cold medicines can lead to various side effects. Here are some of the notable effects:
1. Sedation and Cognitive Impairment : First-generation antihistamines, such as diphenhydramine (Benadryl), are known for causing drowsiness, which can impact coordination, reaction time, and overall cognitive function. This can affect daily activities, including driving and operating machinery【6†source】【7†source】.
2. Dry Mouth and Mucosal Dryness : Both first-generation and some non-drowsy antihistamines can cause dry mouth, dry eyes, and dry nasal passages. This is due to their anticholinergic effects, which reduce saliva and mucus production【6†source】【7†source】.
3. Increased Risk of Liver Injury : Though rare, prolonged use of certain antihistamines has been linked to liver damage. Medications such as cyproheptadine, cetirizine, and terfenadine (now discontinued) have been associated with mild, self-limiting liver injury【7†source】.
4. Tolerance and Rebound Symptoms : Continuous use of some antihistamines can lead to tolerance, where the medication becomes less effective over time. In some cases, stopping the medication suddenly can cause rebound symptoms, worsening the original condition it was treating【7†source】.
5. Potential for Increased Blood Pressure and Heart Rate : Some cold medications, especially those containing decongestants like pseudoephedrine, can increase blood pressure and heart rate. This can be particularly concerning for individuals with underlying cardiovascular conditions【6†source】.
It's important to consult a healthcare provider before using these medications long-term to understand the risks and benefits specific to your health situation.
Written by Pharmacist: Amit Hegade (B.Pharmacy)
References:
Here is the reference list for the information provided:
1. NHS. "Antihistamines." [NHS](https://www.nhs.uk)【6†source】.
2. HealthShare. "What are the long term effects of taking antihistamines?" [HealthShare](https://www.healthshare.com.au)【7†source】.